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​​​The National Metrology Institute of South Africa (NMISA) was established under the Measurement Units and Measurement Standards Act No 18 of 2006. The NMISA is responsible for maintaining the SI units and to maintain and develop primary scientific standards of physical quantities for SA and compare those standards with other national standards to ensure global measurement equivalence.

The institute furthermore must provide reference analysis in the case of a measurement dispute and maintain and develop primary methods for chemical analysis to certify reference materials for SA and the region.